Curriculum Vitae of

Dr Modupe Elebute

MBBS MD FRCP FRCPath

GMC Number: 4079538

Medical Training

  • Qualified in Medicine from Lagos, Nigeria in 1986,
  • Completion of postgraduate training in General Medicine in London and Kent
  • Specialist haematology training at centres of excellence in London including St Bartholomew’s Hospital, St George’s Hospital and The Royal Marsden.
  • Undertook research funded by a prestigious Leukaemia Research Fellowship to study bone marrow failure syndromes for which I was awarded a Doctor of Medicine (MD) degree by the University of London.

Current Appointments 

  • I have practising privileges including inpatient admission rights at a number of London’s leading private hospitals.
  • I am a Fellow of The Royal College of Physicians and The Royal College of Pathologists and a member of The British Medical Association, The British Society for Haematology and The American Society of Haematology.

Clinical, Research and Management Experience

I have held Consultant and Honorary Senior Lecturer posts at St George’s Hospital, the National Blood Service and King’s College Hospital and now work solely in private practice.

My roles have involved:

  • Running general and specialist outpatient clinics
  • In-patient treatment of a wide variety of conditions including chemotherapy and stem cell transplants
  • Responsible clinician for the Blood Transfusion service in large hospitals managing trauma cases
  • Overall management of the haematology laboratory including budgetary responsibility.
  • Setting up a nationally-commissioned service for a rare condition funded by NHS England at King’s College Hospital.
  • Forming an effective multi-disciplinary team across a number of specialties, I worked closely with patients and their families as well as referring colleagues and health care commissioners to provide a service of international reputation.

I have been Principal Investigator for several clinical trials investigating new treatments for patients and implementing positive results to improve patient care and their long-term survival.

My work has been published in scientific journals including the New England Journal of Medicine, British Journal of Haematology and Experimental Hematology.

I have been an invited speaker at several local and international meetings; I have given talks throughout Europe, the USA, Canada and in Nigeria.

I have helped to set up Pathology laboratories in the private and public healthcare set up in Nigeria. I have been involved in the care of several sickle cell patients and co-wrote a handbook for Sickle Cell patients and their families.

A passionate and ardent teacher, I have taught undergraduate and postgraduate medical students as well as to allied professionals including nurses, pharmacists and physiotherapists. I helped to develop the undergraduate Haematology curriculum at St George’s University of London and was Director of Postgraduate Training for Haematology for the South West Thames Region. I have been Educational Supervisor and mentor to several trainees, most of whom are now in established Consultant posts!

Employment history  

Dr Elebute has held Consultant and Honorary Senior Lecturer posts at St George’s Hospital, the National Blood Service and King’s College Hospital but now works solely in private practice.

At St George’s Hospital, she was Lead Clinician for the Haematology Laboratory and for Transfusion Medicine. She ran general and specialist clinics and developed a tertiary service for the management of autoimmune cytopenias. She was Principal Investigator for a number of clinical trials investigating the role of novel monoclonal antibodies in the treatment of refractory autoimmune cytopenias and Paroxysmal Nocturnal Haemoglobinuria (PNH). She was Director of Training for Haematology at St. George’s and the South West Thames Region and was involved in the development of the undergraduate Haematology curriculum at St George’s University of London.

At King’s College Hospital, she was Lead Clinician for the National PNH service, Educational Supervisor and co-chief investigator for a large UK study of the use of prion filters in transfused patients funded by a £1.8 million study grant from the Department of Health. She is widely published in the scientific and clinical literature.

April 2002 to date
Consultant Haematologist, Spire St Anthony’s Hospital, Cheam.

April 2012 – April 2014
Honorary Consultant Haematologist, King’s College Hospital Foundation Trust, London.

April 2008 – April 2012
Consultant Haematologist & lead for PNH National Service, King’s College Hospital.

July 2002 – April 2008
Consultant/Honorary Senior Lecturer in Haematology & Transfusion Medicine, St. George’s Hospital NHS Trust, London and the National Blood Service, UK.

December 2001 – June 2002
Specialist Registrar in Haematology, South West Thames Regional Health Authority

March – November 2001
Locum Consultant, Kingston Hospital NHS Trust, Kingston, Surrey

July 2000 – February 2001
Specialist Registrar in Haematology, South West Thames Regional Health Authority

July 1998 – June 2000
LRF Clinical Research Fellow, St George’s Hospital Medical School

April 1993 – June 1998
Specialist Registrar in Haematology, South West Thames

February 1992 – April 1993
SHO rotation in General Medicine, William Harvey Hospital, Ashford, Kent

October 1989 – January 1992
Registrar in Haematology, St. Bartholomew’s Hospital, London

July – September 1989
Locum SHO, Pathology, Dudley Road Hospital, Birmingham

October 1988 – May 1989
Clinical Attachments in the UK and PLAB exam

August 1986 – July 1988
PRHO & SHO posts, Lagos University Teaching Hospital

Membership of professional organisations

  • The British Society for Haematology
  • The British Blood Transfusion Society
  • The International PNH Interest Group (I-PIG)
  • The American Society for Haematology
  • The American Society for Apheresis

Other appointments

  • Member, St George’s Hospital Transfusion Committee, 2002 to 2008
  • SpR trainer for Haematology, St George’s Hospital, 2003 to 2008
  • Clinical lead, Laboratory Haematology, St George’s Hospital, 2003 to 2006
  • Member of interview panel for MBBS course, SGUL, 2004 to 2008
  • Programme Director, SW Thames Haematology Training Committee, 2004 to 2006
  • Member, UK Prion Removal Working Group (PRWG), 2005 to 2011
  • Co-chief investigator, PRISM study, MRC/NHSBT Clinical Trials Unit, 2004 to 2011
  • Educational Supervisor, King’s College Hospital, 2009 to 2012
  • Member, International PNH Group (I-PIG), 2008 to date
  • Member, PNH Alliance, 2009 to 2012

Special interests

  • Rapid investigation of abnormal blood counts and providing a consultative service to patients, GPs and hospital colleagues
  • Anticoagulant advice and management including guidance on warfarin alternatives
  • Management of patients with clotting disorders (thrombophilia)
    Investigation and treatment of patients with bleeding disorders
    Transfusion Medicine including guidance on alternatives
  • Autoimmune blood disorders and bone marrow failure syndromes
    Malignant Haematology including Myeloma, Myeloproliferative disorders, chronic leukaemias and low-grade lymphomas

Research Projects

  • LRF Clinical Training Fellowship (1998-2000): Isolation and evaluation of normal primitive haemopoietic progenitor cells from patients with haemolytic PNH and potential application for autologous stem cell transplantation.
  • Principal Investigator for open-label study of the effect of ECULIZUMAB (h5G.1-mAb) on patients with transfusion dependent haemolytic PNH. LREC 03.0199; 2004.
  • Principal Investigator for Phase I/II study of Rituximab (Mabthera) for the treatment of refractory autoimmune cytopenias. LREC 02.96.7; 2004-2006.
  • Principal Investigator for safety and efficacy study of Eculizumab in PNH; 2004 to 2006.
  • Co-Chief Investigator of NBS/MRC Trial of Prion-filters in transfused patients; UK DOH grant of £1.8 million (2007 – 2012).

Publications

M.O. Elebute and R. Kesse-Adu: Acquired haemolytic anaemias. In Postgraduate Haematology 7th edition. Editor A. Victor Hoffbrand, Wiley Blackwell 2015, chapter 9.

E.C. Gordon-Smith and M.O. Elebute: Acquired haemolytic anaemias. In Postgraduate Haematology 6th edition. Eds Hoffbrand, Catovsky, Tuddenham and Green. Wiley Blackwell 2010, chapter 10.

M.O. Elebute, C. A Navarette, S. Stanworth: Platelet and granulocyte transfusions. In ABC of Transfusion Medicine 4th Edition. Ed Marcela Contreras, Wiley (2009)

M.O Elebute, E. Massey, S. Benjamin & S. Stanworth for the NBS Transfusion Medicine Clinical Policies Group: Clinical guidelines for the use of granulocyte transfusions. National Blood Service Policy document: INF/MED/MA/006/01 (2004).

M.O Elebute: Haematology. In Basic Sciences for Obstetrics and Gynaecology: core material for Part 1 MRCOG 1st edition. Ed A. Ugwumadu, Oxford University Press, 2014.

M.O Elebute and Judith C Marsh: Autoimmune cytopenias. In Medicine, volume 37, issue 3, March 2009, p 159-163.

Marsh JCW, Elebute MO, Bevan DH. Special circumstances: Jehovah’s witnesses, those who refuse blood transfusion and/or consent. In: textbook of Postpartum Hemorrhage: A comprehensive guide to evaluation, management and surgical intervention. Eds C B-Lynch, L. Keith, A. LaLonde, M Karoshi. D. Sapiens Publishing. 2006, p 147-154

P Hillmen, Muus P, Röth A, Elebute MO, Risitano AM, Schrezenmeier H, Szer J, Browne P, Maciejewski JP, Schubert J, Urbano-Ispizua A, de Castro C, Socié G, Brodsky RA: Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2013 Jul;162 (1):62-73.

Marsh JC, Bacigalupo A, Schrezenmeier H, Tichelli A, Risitano AM, Passweg JR, Killick SB, Warren AJ, Foukaneli T, Aljurf M, Al-Zahrani HA, Höchsmann B, Schafhausen P, Roth A, Franzke A, Brummendorf TH, Dufour C, Oneto R, Sedgwick P, Barrois A, Kordasti S, Elebute MO, Mufti GJ, Socie G; European Blood and Marrow Transplant Group Severe Aplastic Anaemia Working Party: Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party. Blood. 2012 Jun 7; 119 (23):5391-6

P Hillmen, Elebute M.O, Kelly R, Urbano-Ispizua A, Hill A, Rother RP, Khusigara G, Fu CL, Omine M, Browne P, Rosse W: Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria. Am J Hematol (2010) Aug; 85 (8): 553-9

Schubert J, Hillmen P; Roth A, Young NS, Elebute M.O, Szer J, Gianfaldoni G, Socie G, Browne P, geller R, Rother RP, Muus P: Eculizumab, a terminal complement inhibitor, improves anaemia in patients with paroxysmal nocturnal haemoglobinuria. BrJ Haematol. (2008) Jun; 142 (2): 263-72

Hillmen P, Young NS, Schubert J, Brodsky RA, Socié G, Muus P, Röth A, Szer J, Elebute M.O., Nakamura R, Browne P, Risitano AM, Hill A, Schrezenmeier H, Fu C. L, Maciejewski J, Rollins S. A, Mojcik C. F, Rother R. P, Luzzatto L: The complement inhibitor Eculizumab in paroxysmal nocturnal hemoglobinuria. New England Journal of Medicine. (2006) Sep 21; 355 (12):1233-43

J. Cullen, S. J. Richards, S. A. Rollins, C. F. Mojcik & R. P. Rother, Elebute MO: Effect of Eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal haemoglobinuria. New England Journal of Medicine (2004) 350: 552-9

M.O. Elebute, S. Rizzo, J. A. Tooze, J. C. W. Marsh, E.C. Gordon-Smith & F.M.   Gibson: Evaluation of the haemopoietic response in de novo haemolytic paroxysmal nocturnal haemoglobinuria. British Journal of Haematology (2003), 123, 552-560

M.O. Elebute, S.E. Ball, E.C. Gordon-Smith, D. Sage & J.C.W. Marsh: Autologous recovery following non-myeloablative unrelated donor bone marrow transplantation for severe aplastic anaemia. Annals of Haematology (2002), 81: 378-381

C.V. Cox, S.B. Killick, S Patel, M.O. Elebute, J.C.W. Marsh, E.C. Gordon-Smith & F.M. Gibson: In-vitro proliferation and differentiation of megakaryocytic progenitors in patients with aplastic anaemia, paroxysmal nocturnal haemoglobinuria and the myelodysplastic syndromes. Stem Cells (2000) 18, 428-434

Elebute MO, Choo L, Mora A, MacRury C, Llewelyn C, Purohit S, Hicks V, Casey C, Malfroy M, Deary A, Reed T, Meredith S, Manson L, Williamson LM: Transfusion of prion-filtered red cells does not increase the rate of alloimmunization or transfusion reactions in patients: results of the UK trial of prion-filtered versus standard red cells in surgical patients (PRISM A). Br J Haematol. 2013 Mar; 160 (5):701-8.

Gooneratne L, Giorgini A, Elebute MO, Marsh J, Ireland R: Aplastic anaemia and PNH transformation with deposition of liver iron. Br J Haematol. 2012 Jun;157 (5):518.

Robak T, Salama A, Kovaleva L, Vyhovska Y, Davies SV, Mazzucconi MG, Zenker O, Kiessling P; International Privigen in ITP Study Group: Efficacy and safety of Privigen, a novel liquid intravenous immunoglobulin formulation, in adolescent and adult patients with chronic immune thrombocytopenic purpura. Hematology. 2009 Aug; 14 (4):227-36.

Dungarwalla M, Marsh J.C, Tooze J.A, Lucas G, Ouwehand W, Pettengell R, Dearden CE, Gordon Smith EC, Elebute M.O: Lack of clinical efficacy of Rituximab in the treatment of autoimmune neutropenia and pure red cell aplasia: implications for their pathophysiology. Annals of Haematology. (2007) Mar; 86 (3): 191-197

Hill A, Hillmen P, Richards S.J, Elebute MO, Marsh J.C, Chan J, Mojcik C.F, Rother R. P: Sustained response and long-term safety of Eculizumab in paroxysmal nocturnal hemoglobinuria. Blood (2005) Oct 1; 106 (7): 2559-65

P. Hillmen, C. Hall, J. C. W. Marsh, M.O. Elebute, Bombara, B. S. Petro, M. J. Cullen, S. J. Richards, S. A. Rollins, C. F. Mojcik & R. P. Rother: Effect of Eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal haemoglobinuria. New England Journal of Medicine (2004) 350: 552-9

J.C.W. Marsh & M.O. Elebute: Stem cells in paroxysmal nocturnal haemoglobinuria and aplastic anaemia: increasing evidence for overlap of haemopoietic defect. Transfusion Medicine (2003), 13, 377-386

M. Ismail, J. A. Tooze, J.A. Flynn, E.C. Gordon-Smith, F.M. Gibson T.R Rutherford & M.O. Elebute: Differential apoptosis and Fas expression on GPI-negative and GPI-positive stem cells – a mechanism for the evolution of paroxysmal nocturnal haemoglobinuria. British Journal of Haematology (2003), 123, 545-551

Rizzo, J. Scopes, M.O. Elebute, H.A Papadaki, E.C. Gordon-Smith & F.M. Gibson: Stem cell defect in Aplastic Anaemia: reduced long term culture-initiating cells (LTC-IC) in CD34+ cells isolated from aplastic anaemia patient bone marrow. Haematology Journal. (2002), 3, 230-236

N.J. Philpott, M.O. Elebute, R. Powles, J.G. Treleaven, M. Gore, M.G. Dainton, T. Min, G.J. Swansbury & D. Catovsky: Platinum agents and secondary myeloid leukaemia: two cases treated only with platinum-based drugs. British Journal of Haematology (1996) 93 (4): 884-7

Personal informaton

I am married with 3 children. Passionate about giving back, I helped to set up The Sickle Cell Club of Lagos and have raised significant funds for charitable causes.

I am Patron of Build Africa and Trustee of The Walkabout Foundation